To use these women's Brooks Glycerin GTS 22 running shoes, simply lace them up and you're ready to hit the road. When running, you'll notice the soft cushioning that makes each step comfortable and the support system that keeps you on track. For maintenance, clean the shoes regularly with a soft brush and mild soap to keep them looking good. Avoid exposing them to extreme heat or harsh chemicals as this may damage the materials. Also, check the laces periodically to ensure they are in good condition and replace them if needed. Store the shoes in a cool, dry place when not in use to maintain their shape and performance.